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Cellular Dynamics’ iCell Hepatocytes Enable Malaria-in-a-Dish Studies

MADISON, Wis., Feb. 11, 2015 (GLOBE NEWSWIRE) — Cellular Dynamics International (CDI) (Nasdaq:ICEL) today announced that its iCell® Hepatocytes, or human liver cells manufactured from induced pluripotent stem cells (iPSCs), have been used as a malaria-in-a-dish model to test anti-malarial drug candidates. Sangeeta N. Bhatia, M.D., Ph.D., of the Institute for Medical Engineering and Science, Massachusetts Institute of Technology, infected the iPSC-derived hepatocytes with parasitic Plasmodium species, characterized the cells’ drug metabolism capabilities using known antimalarial drugs, and chemically matured the cells to demonstrate higher sensitivity to a different class of drugs. The study was published inStem Cell Reports.

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