The investigational, potent, oral CDK9 inhibitor, zotiraciclib (ZTR/TG02) in combination with temozolomide (Temodar), demonstrated early improvement in progression-free survival (PFS) as treatment of patients with recurrent high-grade gliomas, meeting the primary end point of the phase 1B 17-C-0009 trial clinical trial (NCT02942264). Topline results announced in a press release by the developer of zotiraciclib, Adastra […]

While pharma has raced to develop COVID-19 vaccines, US-based company NeuroRx is taking a different approach to treating the virus. CEO Dr. Jonathan Javitt tells pharmaphorum about the science behind the company’s Zyesami, which targets the alveolar type II cells in the lung that are critical for transmission of oxygen. Zyesami was developed in conjunction […]

Like many biopharma companies, the global COVID-19 pandemic has caused delays while also offering opportunities for NeuroRx. The company is based in Radnor, Pennsylvania, and typically is focused on the central nervous system space, developing NRX-100/NRX-101, for suicidal bipolar depression and other neurological disorders. Those trials, however, were suspended because of the pandemic. But, during […]