Despite the success of CAR-T therapies for B-cell cancers and multiple myeloma, developing CAR-T therapies for solid tumors has posed more of a challenge. Failure of the CAR-T cells to multiply to high enough levels, the tumor microenvironment being immunosuppressive, and tumor cells ‘escaping’ the therapy by losing target antigen expression are just some of […]

When it comes to getting a drug into a cell, size matters. Small molecules can easily pass through the cellular membrane in a way that larger therapeutic proteins can’t, which makes it difficult to develop a biological drug that can reach its target, says Dipal Doshi, CEO of biotech startup Entrada Therapeutics.